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Evolution of Enzyme Function and the Development of Catalytic Efficiency: Triosephosphate Isomerase, Jeremy R. Knowles, and W. John AlberyEvolution of Enzyme Function and the Development of Catalytic Efficiency: Triosephosphate Isomerase, Jeremy R. Knowles, and W. John Albery

Each reader is aware of that an enzyme accelerates a response by lowering the activation-energy barrier. Nevertheless, understanding how that is achieved by the construction of the enzyme and its interactions with